Manufacturers Supply High Quality Sitagliptin Raw with Best Price CAS 486460-32-6

Manufacturers Supply High Quality Sitagliptin Raw with Best Price CAS 486460-32-6

• Product description

• Product name	Valsartan Methyl Ester
  CAS No.	486460-32-6
  Molecular Formula	C16H15F6N5O
  Molecular weight	407.31
  Grade Standard	Medicine Grade
  COA	Avaliable

• Product introduction

• Sitagliptin is an oral antihyperglycemic of the dipeptidyl peptidase-4  inhibitor class. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents for treatment of diabetes mellitus type 2.The benefit of this medicine is its fewer side effects in the control of blood glucose values. While safety is its advantage, efficacy is often challenged as it is often recommended to be combined with other agents such as metformin.

• Product application

This drug is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which controls the blood glucose level by protecting endogenous enteroglucagon and enhancing its effect. Glucose dependent in sulin releasing peptide (GIP) and glucagon like peptide-1 (GLP-1) are intestinal glucagon released for dietary intake.
GLP-1 and GIP can increase in sulin synthesis and release from pancreatic islets through intracellular signal pathway β GLP-1 can also reduce the release of islets α Cells secrete glucagon and reduce hepatic glucose production. However, GLP-1 and GIP are rapidly metabolized by DPP-4, resulting in the loss of its in sulin promoting effect.
This drug inhibits the degradation of enteroglucagon by DPP-4, so it can enhance the functions of GLP-1 and GIP, increase in sulin release and reduce the level of glucagon in circulation (this effect is Glucose dependent). The drug selectively inhibits DPP-4 and has no inhibitory activity on dpp-8 or dpp-9.