Description
Anti Estrogen Trilostane Raw Steroid Powder CAS 13647-35-3 For Breast Cancer
Description
| CAS No.: | 13647-35-3 | Name: | Trilostane |
|---|---|---|---|
| Molecular Formula: | C20H27NO3 | Molecular Weight: | 329.43 |
| Melting Point: | 264 °C | Storage: | 2-8°C |
| Appearance: | Powder | Other Name: | Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)- |
| High Light: |
Trilostane Raw Steroid Powder, Raw Steroid Powder CAS 13647-35-3, Anti Estrogen |
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Anti Estrogen Apis Raw Steroid Powder Trilostane CAS 13647-35-3 for Breast Cancer
Product introduction
| Item | Specifications |
| Appearance | White to tan powder. |
| Purity | 99%min |
| Melting point | 264ºC |
| Boiling point | 467.02ºC(rough estimate) |
| Density | 1.1213 (rough estimate) |
| Specific rotation | 25 +137.4° (c = 1 in pyridine) |
| Refractive index | 1.5614 (estimate) |
| Solubility | DMSO: ≥17mg/mL |
| Storage condition | -20ºC Freezer |
| Shelf life | 2 years |
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3∫-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production of dihydrotestosterone in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
Function and Application
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing’s syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Before taking this medicine
The dose of product will be different for different patients. Follow your doctor’s orders.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
All products are exported for Lab & Research use in legal and Non-patented area only. Products may not be used in human or animals. Individuals are fully responsible for all consequences arising therefrom.
