White Solid Sunifiram Powder Api Pharmaceutical Ingredients CAS 314728 85 3

Product Details:

Place of Origin: China
Brand Name: Changland
Certification: GMP/ISO
Model Number: 28

Payment & Shipping Terms:

Minimum Order Quantity: 100g
Price: To be negotiated
Packaging Details: foil bag, drum, vials
Delivery Time: 4-5days
Payment Terms: Western union/ money gram/bitcoin/bank transfer/Credit card
Supply Ability: 10000g per week
Category:

Description

White Solid Sunifiram Powder Api Pharmaceutical Ingredients CAS 314728 85 3

Description

Product Name: Sunifiram Other Name: 1-(4-Benzoyl-1-piperazinyl)-1-propanone
CAS No: 314728-85-3 MF: C14H18N2O2
MW: 246.3 Purity: 99% Min
Shelf Life: 2 Years Application: Pharmaceutical API
Sample: Available Storage: Cool And Dry Place
High Light:

Api Pharmaceutical Ingredients 314728 85 3

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Sunifiram Powder 314728 85 3

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Sunifiram Powder Api Pharmaceutical Ingredients

 

Pharmaceutical API White Solid Nootropics Powder CAS 314728-85-3 Sunifiram​

 

Product Introduction

Name SunifiraM
English synonyms 1-(4-Benzoyl-1-piperazinyl)-1-propanone
CAS Number 314728-85-3
Molecular formula C14H18N2O2
Molecular weight 246.3
EINECS number 1312995-182-4

Product Description

Melting point /
Boiling point 442.0±38.0 °C(Predicted)
Density 1.154±0.06 g/cm3 (20 ºC 760 Torr)
Solubility H2O: soluble24mg/mL
Storage 2-8°C
Acidity coefficient (pKa) 0.08±0.70(Predicted)

Product Function

Sunifiram (DM235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency thanpiracetam. A number of related compounds are known, the best known being unifiram (DM-232).

This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycinebinding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.